Alternating Hemiplegia of Childhood (AHC)

Cure AHC Multi-Electrode Array Project

AHC is a rare, severe neurodevelopmental syndrome that affects 1 in 1,000,000 children. Symptoms include movement problems similar to cerebral palsy, bouts of temporary, but sometimes painful paralysis that can last for minutes to days, behavioral problems like ADHD and learning challenges. Additionally, approximately 50% of those diagnosed with AHC also present with true epilepsy. While there is currently no cure or treatment for AHC, great strides have been made in recent years to uncover the underlying cause of this very debilitating disease. With the generous support of CURE AHC, the IGM is seeking to understand how the ion channel dysfunction responsible for AHC affects neuronal activity and how these neurons respond to biologically relevant stimuli, including changes in external conditions, optogenetic stimulation, and pharmacological manipulation. Multielectrode Arrays (MEAs) will be used to detect and analyze spontaneous neuronal activity and evoked activity due to the effect of stimuli.